Figure Shows Typical OCT image of Cornea
OCT was introduced in ophthalmology in the 1990's to make surface images of ocular tissue based on interference patterns generated by mixing two light beams. OCT produces an image.
Vibrational OCT combines the techniques of OCT and Vibrational analysis to generate both
an image and information about mechanical properties of the sample under test. Sound waves are used to generate vibrations.
Changes in mechanical properties of ECM are known to accompany the onset and progression of several diseases including atherosclerosis, cirrhosis and cancer. Tissue stiffness changes with change in the mechanical properties. This difference between stiffness and thus modulus, can be used to differentiate lesions from normal tissues and perform a virtual biopsy. Benign lesions have two resonant frequencies, one from the thickened epidermis that is at about 40 Hz for the epidermis and one at 140 to 160 Hz that represents the collagen component. Malignant lesions have two resonant frequencies; the epidermal peak is broadened and shifted to the left which the collagen peak is broadened
Modulus mismatch between host tissue and implant material contribute to implant failure. The use of VOCT can help image and measure the mechanical properties of numerous natural and synthetic polymers.
The Modulus as seen predicted with VOCT is comparable to that calculated with the help of tensile testing. The image above shows a tabulation for different samples and their modulus.