2020 Hamilton St, Allentown, Pennsylvania 18104, United States

610-433-0600 , 610-428-2173

Optical Coherence Tomography (OCT)


Figure Shows Typical OCT image of Cornea

OCT was introduced in ophthalmology in the 1990's to make surface images of ocular tissue based on interference patterns generated by mixing two light beams. OCT produces an image. 

Vibrational Optical Coherence Tomography (VOCT)


Vibrational OCT combines the techniques of      OCT and VIbrational analysis to generate both

an image and information about mechanical properties of the sample under test. Sound waves are used to generate vibrations. 

Virtual biopsy


 Changes in mechanical properties of ECM are known to accompany the onset and progression of several diseases including atherosclerosis, cirrhosis and cancer. Tissue stiffness changes with change in the mechanical properties. This difference between stiffness and thus modulus, can be used to differentiate lesions from normal tissues and perform a virtual biopsy.    Benign lesions have two resonant frequencies, one from the thickened epidermis that is at about 40 Hz for the epidermis and one at 140 to 160 Hz that represents the collagen component.  Malignant lesions have two resonant frequencies; the epidermal peak is broadened and shifted to the left which the collagen peak is broadened 

Implant Characterization


 Modulus mismatch between host tissue and implant material contribute to implant failure. The use of VOCT can help image and measure the mechanical properties of numerous natural and synthetic polymers.   

Results are Comparable to Gold Standard Method


 The Modulus as seen predicted with VOCT is comparable to that calculated with the help of tensile testing. The image above shows a tabulation for different samples and their modulus. 

Advantages over competing Techniques



  • Uses Low power infrared light for imaging and an audible sound less than 60 dB is utilized for generating vibrations.  
  • Does not make an assumption for Poisson's ratio unlike other techniques.



  1.  Virtual biopsies for Moh's surgical Procedure 
  2.  Identification of change in tissue stiffness for Cancerous lesions 
  3.  Characterization of tissues and implants 
  4.  Margins for skin lesions 
  5.  Identification of lesion types
  6.  Identification of breast tissue biopsies
  7.  Identification of corneal and scleral pathology
  8.  Quantitative assessment of carotid artery behavior
  9.  Identification of injection site blood vessels
  10.  Quantification of tissue water content
  11.  Analysis of dermal wound healing
  12.  Mechanical Testing